A descriptive study was conducted on 60 nursing personnel in Rama Medical College Hospital and Research Centre, Mandhana Kanpur, to evaluate the knowledge of nursing personnel regarding care of neonates in selected hospital Kanpur Study was conducted at Rama medical college Hospital and Research Centre, Mandhana Kanpur. 60 nursing personnel were selected by convenient sampling technique. According to UNICEF (2009) 26% of neonatal death is due to neonatal sepsis, 27% is due to preterm,23% is due to asphyxia,7% is due to tetanus, 3% is due to diarrheal disease, 7% is due to congenital disease, 7% is due to others