Ventilator associated pneumonia (VAP) is pneumonia developing in a mechanically ventilated patient more than 48 hours after endotracheal intubation. It is one of the leading causes of death among hospitalacquired infections. The research design consisted of an evaluative approach with Pre -experimental one group pretest post- test design. Samples were selected by convenient sampling technique. The data was collected using structured knowledge questionnaire. The mean pre-test knowledge score was 24.2. and post test knowledge score was 38.74 at 0.05 level of significance. Standard deviation of pretest is 3.62 for post test is 3.39 which indicates that the STP was effective in increasing knowledge of staff nurse regarding prevention of ventilator associated pneumonia