Degenerative arthritis is a condition in which inflammation and pain occur due to gradual damage to the cartilage or degenerative changes. The number of degenerative arthritis patients is on the rise every year, and more than 80 percent of those 55 years old. Therefore, the paper measures the effectiveness of the optimal integrated information system for strengthening immunity in patients with knee degenerative arthritis. Changes in arthritis in the application of the integrated information system over time were analyzed by a t-test. The results of the paper are as follows.