This research on the enhancement of community participation to create safe areas in response to the spread of the COVID-19 virus in the area of Kalayani Vadhana district, Chiang Mai province was conducted with the objectives to study the behavior of people in communities in the period before the occurrence of the spread, during the pandemic, and after relaxation of the measures of control of the government, to study the role of communities for the enhancement of participation in preventing the spread of the virus, and to propose guidelines for community participation to create areas that are safe from the spread of the virus. The research was conducted as a mixed methods approach by using a system of research methods combining three types, which were 1) documentary research, 2) a quantitative research set, and 3) qualitative research with in-depth interviews and focus groups. The research results indicate that the behavior of people in communities in the period before the occurrence of the spread was that some groups of people in communities gathered together to form large clusters. With regard to health, some groups were interested in matters of health and wellness, whereas other groups neglected them. The behavior during the pandemic included people in communities implementing social distancing, taking care of the health of both themselves and the people around them, and doing more activities inside their homes, and as for the behavior after the relaxation of the measures of control of the government, some groups of people in communities returned to living life normally, but most people in communities have continued taking precautions in terms of their health. The role of communities is considered to be the process that encourages the relationships of people in communities and the government agencies in areas as well as taking the actions that lead to the exchange and adjustment of methods and the monitoring and prevention of the pandemic that are specific to the context of each area, which is an effective way to create safe areas by using the mechanisms of Action Research.