Mucin-1 is a protein coding gene which located on chromosome 1 q22 part. The current study focuses on MUC 1 polymorphism and expression with infertility in Iraqi females. This study included 72 females divided into: forty infertile women and thirty-two fertile women. The present study found three SNPs in Mucin-1 gene and has been determined in Iraqi females. The rs145224844 showed three genotypes CC, CA, AA. No statically significant differences among the three genotypes between fertile and infertile were found. The odds ratio referred that C allele acting as protective allele while A allele could have the ability to associate with the disease. While rs139620330 showed three genotypes TT, TC, CC with no significant differences between fertile and infertile.