This study examines the impact of information asymmetry on the relationship between corporate reputation and cost of equity in companies listed on the Tehran Stock Exchange. This research is applied research in terms of its purpose and descriptive correlation in terms of the research method. The statistical society population of this research includes the companies listed in the Tehran Stock Exchange as 193 companies operating in various industries over the years 2011 to 2019. The method of hypothesis testing in the present study is the use of multivariate regression, which was done using EViews software. The results of the research show that there is no significant relationship between corporate reputation and cost of equity, and information asymmetry does not moderate this relationship.