Taking Peirce’s logical semeiotics as the theoretical framework, this paper aims to comb out the notion of Peircean dialogue with a special reference to Peirce’s elaborations of signs, sign classification, sign interpretation, semiosis, and semiotic research. To go a step further, this paper explores the notion of dialogue from the perspective of the Theory of Inquiry, which is the core of Peirce’s philosophy. It shows that dialogical features are pervasive in Peircean semiotics and logic. Dialogue in semiotics does not solely refer to a communicative way of sign generation and sign interpretation in its narrowest sense, but it can be systematized as the interpretive routes of Peircean interpretation and communication.