Background: The first COVID-19 vaccine was authorized in the United States in December 2020. It is recognized that vaccination is a preventive and effective measure for limiting the coronavirus pandemic. Nursing students' perspectives on vaccine acceptance may be critical for COVID-19 pandemic prevention as future professionals. The study has focused on perceptions of nursing students regarding coronavirus vaccine acceptance.Design: This study was conducted using a sequential explanatory mixed-methods design with two phases. Methods: A convenience sample method was applied in phase one, and 255 nursing school students between February 14 and February 24, 2022, from six universities in Iraq participated. The findings were used in phase two to refine in-depth interview questions that would allow for a deeper investigation of student perceptions.