This article describes the efforts of the Papuan province administration in dealing with coronavirus cases (Corona Virus Disease-19) (COVID-19). The approach for dealing with it may be examined by knowing the efforts, actions, and policies created and executed by the Papuan provincial government. A deliberative policy analysis technique is employed to analyze this situation. This method examines the narratives and arguments of authorities in order to comprehend decision-making and policy execution. This essay takes a qualitative approach, using descriptive analytic methodologies. Meanwhile, a literature research is being utilized to gather data, which includes books, journal articles, newspapers, internet news, and authoritative institution websites. The findings demonstrate that the COVID-19 epidemic has had a substantial influence on the people who live in the region, beginning with increased unemployment, food poverty, migration owing to job instability, increased criminality, and so on. Various laws have been established to combat the epidemic as a form of responsibility for the Papuan administration to the people, including the closure of human entry to Papua province. This is accomplished by shutting down airports and seaports. This policy is considered as contradictory to the central government's policies. This study concluded that wisdom is required in reacting to measures implemented by local governments to rescue persons impacted by the COVID-19 pandemic since they are better aware of the situations in their region.This article describes the efforts of the Papuan province administration in dealing with coronavirus cases (Corona Virus Disease-19) (COVID-19). The approach for dealing with it may be examined by knowing the efforts, actions, and policies created and executed by the Papuan provincial government. A deliberative policy analysis technique is employed to analyze this situation. This method examines the narratives and arguments of authorities in order to comprehend decision-making and policy execution. This essay takes a qualitative approach, using descriptive analytic methodologies. Meanwhile, a literature research is being utilized to gather data, which includes books, journal articles, newspapers, internet news, and authoritative institution websites. The findings demonstrate that the COVID-19 epidemic has had a substantial influence on the people who live in the region, beginning with increased unemployment, food poverty, migration owing to job instability, increased criminality, and so on. Various laws have been established to combat the epidemic as a form of responsibility for the Papuan administration to the people, including the closure of human entry to Papua province. This is accomplished by shutting down airports and seaports. This policy is considered as contradictory to the central government's policies. This study concluded that wisdom is required in reacting to measures implemented by local governments to rescue persons impacted by the COVID-19 pandemic since they are better aware of the situations in their region.