The COVID-19 outbreak has continued to affect the economy, especially Thailand, which has driven the country's economy from small and medium-sized businesses. This article aims to study the problems affecting SMEs from the epidemic crisis in Thailand, classified by 2 business groups: medium-sized businesses and small businesses consists of manufacturing businesses, Wholesale and retail business, and service businesses by studying from small and medium-sized business entrepreneurs in Thailand. A total of 500 cases were collected using electronic questionnaires via the Internet.