A mixed method study was conducted to explore the quality of life and infertility stigma of infertility couples undergoing in vitro fertilization. (94 couples) one hundred and eightyeight participants were selected from different fertility centers in Jordan from April to November 2022. To gather the data infertility stigma scale, quality of life scale, and semistructured interviews have been adopted. Findings of the study showed that the infertility stigma levels were high among the participants, on another hand the level of quality of life was low. Furthermore, the finding presented a strong negative relationship between quality of life and infertility stigma, and the infertility stigma affects a high degree of variance in quality of life. The study presented that the term infertility stigma was perceived as a social, public, family, and environmental stigma.