Blast loading and earthquake excitations can be regarded as the most destructive events a building structure can experience during its life. For studying the response of the blast loading on structures the seven story building has been taking that is modeled in the ETABs. The response of different loading are studied on the structure. IS 4991-1968 are used for comparable study of the behavior of the structure on different applied loads. The results show that the lateral story drifts produced by blast loading are significantly larger than the corresponding seismic drifts. The study concludes that consideration of the global response of a building to blast loads is important, and response parameters, such as the lateral drifts and floor responses, should be paid attention in the design and response assessment procedures for blast loading. First, a quick explanation of explosives and their various varieties has been provided. Furthermore, the general characteristics of the explosion process have been studied on different loadings