This study (the Azerbaijani-Armenian conflict and the future of the Nagorno-Karabakh region) is important because of the resurgence of conflict between Azerbaijan and Armenia, nearly 22 years after the war between them over the Nagorno-Karabakh region had originally concluded. This war clearly indicates the seriousness of crises based on ethnic-civilizational differences. Added to this is the role of regional and international countries intervening in support of either of the conflicting parties similarly, on the basis of ethnic-civilizational motives. Accordingly, this study aims to examine the events that accompanied the conflict over Nagorno-Karabakh since 2019 and its political and economic consequences for the region as well as the region’s future prospects.