This research aims to identify brain control and its relationship with self-efficacy (academic, social, and emotional). The researcher used the descriptive method through case study and survey methods to achieve the research objectives. The main sample consisted of 400 students representing fifth-grade students in the literary and scientific branches from Al-Karkh Second Preparatory School and Al-Rusafa Third Education, with an equal distribution using stratified sampling from 8 preparatory schools, consisting of 4 boys' schools. To solve the research problem, the researcher used the brain control scale, logical analysis, exploratory application, and statistical analysis of the sample size items. The researcher relied on the self-efficacy scale in accordance with the age group of the students by using the method of reusing the psychological safety measurement and assessing its reliability. The researcher clarified that brain control is represented in mental activity, with the right hemisphere of the brain controlling creative activities, while the left hemisphere controls linguistic activities. The researcher clarified that brain control is related to professional tendencies and self efficacy through making better decisions by students, and that the feeling of psychological security will distance students from the spread of unemployment, fear, incapacity, and despair about the future.