Semiosic universe refers to a universe full of semiosis, dynamic sign process or sign interpretation. The universe, like life, is the action of signs. Semiotically, it is usually by Sebeok a global semiotics. In traditional Chinese medicine (TCM), however, a smaller world of cognition, semiosic universe also exists in the recognition of the world, the construction of the theoretical system and the communication of TCM around the world. The birth of TCM is a semiosis or sign process that the ancient Chinese tried to use their muse to interpret the nature, human and the society. They turned to something metaphysical and intangible to start the origin. From TCM perspective, the whole universe is filled with sign actions or semiosis. It is a semiosic universe.