International cooperation and drug securitization have become a topic of problems currently faced by almost all countries in the world, including Southeast Asia (ASEAN) and Indonesia. In terms of securitization, drugs are a threat to humanity and security. Regarding the perspective of international cooperation, efforts to prevent and eradicate narcotics abuse and trafficking in Indonesia are supported by the implementation of international cooperation. The existence of international cooperation is a must to support the success of strong supportive cooperative efforts whose implementation and results can exacerbate or improve the drug problem. Based on this, this research was conducted to correlate drug securitization with aspects of international cooperation in Indonesia on the issue of drugs in which there are many stakeholders involved in it. This research was conducted qualitatively with data sources derived from observations, interviews, documentation, and visual materials. Researchers also conducted literature studies and web searches to collect supporting data and evaluated using data reduction methods. Research shows that applying the relationship between securitization and Cooperation is a reasonable idea. At least in theory it can be considered for further discussion. By combining the two concepts, we get the possibility of similarities that can be applied together in a discussion. Likewise, there are intersections of some elements of these two concepts that can be analyzed as equal parts. In addition, it is also speculated that in certain cases, Cooperation can be equated with a securitization or is part of securitization, but it does not have securitizing moves and extraordinary measures.