Menstrual attitude refers to the plethora of responses in the Behavioral, and emotional forms held towards the entire menstrual experiences by the adolescent girls and women during their menstruation. Especially the adolescent stage is where girls are encountered in various transformations with their physiological and psychological functioning’s which is also the scope for the attitude formation towards their life. The attitude towards the menstruation has an inevitable influence in the different aspects of life with respect to the psychosocial attributes, which is bolstered by the lot of studies. The current study aims to explore the relationship between the menstrual attitudes and some of the significant psychosocial factors like quality of life, depression, anxiety, and stress. And to identify the critical influential extent of the menstrual attitudes. The study involves 620 adolescent girls ranging between the age 15 and 18. Samples are refined from 4 different private schools in the city of Coimbatore in TamilNadu. The findings state that the attitude held towards menstruation have an influence on the psycho-social attributes like depression, anxiety, stress, and the quality of life. The correlational values shows that the variable menstrual attitude is positively correlated with the quality of life. The psychological distresses like depression, anxiety and stress are negatively correlated with the attitude towards menstruation.