The use of blended learning necessitates academic exploration and attention. The study aimed to assess various challenges in implementing blended learning in the new normal and its effects on Higher Education Institutions. This evidenced-based research used a systematic review guided by the PICO framework and PRISMA search process. The study revealed that BL provides promising results in delivering quality teaching and learning even during the COVID-19 pandemic. Various literature further revealed several roadblocks encountered by learners, teachers, and administration in implementing BL in HEIs. Opportunities were also documented by different authors on how BL improves efficiency and optimum delivery of instruction, as well as individual and collaborative skills, knowledge, and attitude development. The study concludes that using BL ensures continuity of learning in Higher Education Institutions amidst academic restrictions in the new normal. Addressing numerous challenges affecting learners, teachers, and administrators can improve the implementation of BL in the new normal, and blended learning contributes to positive academic performance, engagement, growth, opportunities, and teaching-learning outcomes for both teachers and learners.