The manufacturing industry in Indonesia contributes greatly to gross domestic product and employment, so investment needs to be increased. The era of globalization during the COVID-19 pandemic brought major changes to the world economy. Profitability is one of the main indicators used by investors in investing. The population in Indonesia, which is predominantly Muslim, prioritizes investing in industries that apply sharia principles. For this reason, this study aims to determine the factors that influence the profitability of the manufacturing industry listed on the Indonesian Sharia Stock Index with the exchange rate as a moderating variable. The study used the panel data regression method, with a sample of 30 companies, which were obtained using the purposive sampling method, from manufacturing industry companies listed on the Indonesian Sharia Stock Index in 2013-2020. As for the results, Islamic Social Reporting and Total Assets Turn Offer have a positive effect and significantly to Return on Equity, while COVID-19 has a negative and significant effect on Return on Equity. However, the Current Ratio and Debt to Equity Ratio with the exchange rate as a moderating variable have no effect on Return on Equity