Enterprises are very important for local economic development and growth, but there are internal and external factors that hinder their sustainability. The objective of the research is to identify the difficulties for tourism enterprises in the Province of Chachapoyas, Amazonas, Peru. The study was descriptive with a quantitative approach of non-experimental design, the population was made up of 241 micro and small businesses (Mypes) in the tourism sector in the categories of accommodation, restaurants and travel agencies, obtaining a convenience sample of 52 Mypes, to which a survey was applied. The results show that the internal factors represent a high level of difficulty with 44.2%; external factors represent a medium level in terms of difficulties with 48.1%; followed by a high level with 40.4% and at a general level they show that the difficulties for undertakings in the tourism sector reach 50% for both the high level and the medium level. Concluding that the difficulties for tourism ventures in the Chachapoyas Province of Amazonas of Peru face internal difficulties that reach a majority of 44.2% at a high level and external ones 48.1% at a medium level.