The study examined Family Counselling and Pre-Marital Sexuality among In-School Female Students in Calabar Metropolis, Cross River State, Nigeria. To guide the study, three research questions and hypotheses were posed. The study adopted the ex-post facto research design, with a population of five thousand, nine hundred and eighteen (5,918) female students. The sample comprised 700 in-school female students drawn from the 2 Local Government Areas of the metropolis. A questionnaire developed by the researcher titled “Family counselling and Pre-Marital Sexuality Questionnaire (FCPSQ)” was used for data collection. The data gathered were analyzed with a one-way analysis of variance (ANOVA). The findings revealed that family communication counselling has a significant influence on pre-marital sexuality among in-school female students, family relationship counselling has a significant influence on pre-marital sexuality among in-school female students and there is a significant influence of family structural counselling on pre-marital sexuality among in-school female