The original equipment manufacturer faces the problem of increasing production costs, the number of production base relocations has increased, and a lack of ability to create brands which leading to the need to upgrade to brand ownership. The purpose of this research was to study the approach of guidelines for creating opportunities of the original equipment manufacturer to the original brand manufacturer; mixed-methodology research; quantitative and qualitative research employed in this study. The quantitative data: from a questionnaire of 500 the Thailand Trust Mark Certify using statistical tests of descriptive analysis, inferential analysis, and multivariate analysis. This research shows guidelines composed of 4 aspects. The most important item of each aspects are as following: 1) Brand Commercial (X̅ = 4.67), 2) Marketing Ecology (X̅ = 4.60), 3) Product Innovation (X̅ = 4.54), and 4) Transformation Process (X̅ = 4.43) The analysis of the developed structural equation model showed that it was in accordance and harmony with the empirical data and passed the evaluation criteria. Its Chi-square probability level, relative Chi-square, the goodness of fit index, and root mean square error of approximation were 0.056, 1.124, 0.947, and 0.016, respectively.