Promoting a healthy and active school environment is very important in higher institutions. This study aimed to determine the anthropometric measures, physical activity levels, and wellness lifestyle habits of 1,872 first year college students of the Polytechnic University of the Philippines. Using the descriptive method and quantitative approach, the findings revealed that most of the students were female, ranging from 18-19 years old take part in passive activities during their leisure time. The findings further revealed that the students experience health-related fitness signs and symptoms, diagnosed with Bronchial Asthma, Anemia, history of operation, while lifestyle diseases are the most common family health history. Students also participates in moderate level of activities; however female students perform less vigorous activity than male. Though anthropometric measures are all in normal range, surprisingly, females have lower Body Mass Index (BMI) range compared to males. More so, students have an excellent awareness on key wellness elements except for healthrelated fitness that got poor rating. This study provides significant data that could assist the administrators in developing gender-specific programs, support policies, responsive curriculum, and school interventions for promoting healthy and active lifestyle behaviours among students.