The purpose of this study is the development, based on the modernized Cobb-Douglas production function, the toolkit for diagnosing the economic dynamics of regional socioeconomic systems in the context of economic relations digitalization. The subject of the study is methodical approaches to a formalized assessment of the region digital transformation impact on the parameters and prospects of its economic growth (using the example of the Volga Federal District regions). Based on the results of the study, the models were built that determine the influence degree of the main production factors (labor, capital, digital transformation) on the dynamics of GRP growth in the studied groups of regions.