Digital marketing is a concept that widely acknowledge and known by business entities in B2C market to market their products, nevertheless the digital marketing concept is still difficult to be adopted by the more orthodox and conventional world of Medical Doctor. This study aims to understand the acceptance driver of digital marketing usage of medical nutrition products among medical doctors. The Unified Theory of Acceptance and User of Technology (UTAUT) is adopted and extended by adding the anxiety variable. A structured selfadministered questionnaire was sent to 70 medical doctors in Ho Chi Minh and Hanoi. The study employs variance-based structural equation modelling analysis with the SmartPLS software to test the hypotheses. The study found that drivers for the successful adoption of medical nutrition's digital marketing among medical doctor are e-commerce’s performance expectancy and social influence. Both drivers have a positive effect on the user's behavior intention and adoption of medical nutrition's digital marketing activities. This study provides empirical evidence of how the UTAUT concept can predict and explain the behavior of Medical Doctor upon using digital marketing to provide better service to their patients.