Genetic blood disorders/hemoglobinopathies are a common group of inherited diseases responsible for major physical and mental disabilities. Creating consciousness and teaching the public about the disorder might be cost-powerful withinside the lengthy run, decreasing the frequency of the condition in the society, & making contributions to enhance patients' quality of life. It is crucial to apprehend diverse groups' attention to various hemoglobinopathies and premarital screening and its acceptability to keep away from in addition disparities in fitness care. This systematic review aimed to assess knowledge, attitudes, and perception (KAP) towards different hemoglobinopathies and premarital screening among students, parents, and the general population.