The objectives of this dissertation were 1) to study the innovation in teaching and learning management of Thai traditional medicine for the change of the world in COVID-19 pandemic, 2) to compare the teaching and learning skills of Thai traditional medicine students in the experimental group before and after receiving an online teaching program and developing a model, 3) to propose an effectiveness innovation model of Buddhist in teaching and learning management of Thai traditional medicine in new normal. Multiphase mixed methods research was designed by using quantitative methods to extend qualitative results. It was divided into 3 phases; Phase 1 qualitative research, there were 9 key informants from religious experts, experts of innovations and experts in Thai traditional medicine, and data were analyzed by analytic induction. Phase 2 quasi-experimental research, the sample was calculated using Daniel Soper’s formula, and 116 samples were selected by purposive sampling from online teaching workshops. The data were analyzed by descriptive statistics and statistical testing. Focus group discussion was obtained from purposive sampling of 9 experts, and data were analyzed by content analysis. Phase 3 was quantitative research, a sample of 116 students studying Thai traditional medicine at the Institute of Thai Traditional Medicine Clinic Arokaya, and were selected by purposive sampling. Data were analyzed by using descriptive statistics, Pearson’s Correlation Coefficient and analyzed to validate the model with the empirical data, and analyze the direct and indirect effects. Results were shown that 1) The innovation in teaching and learning management of Thai traditional medicine for the change of the world in COVID-19 pandemic, which consisted of 4 components: (1) innovation in new normal, (2) process of teaching and learning Thai traditional medicine, (3) Buddhist teaching methods, and (4) the effectiveness of teaching and learning innovation. 2) An effectiveness innovation model of Buddhist in teaching and learning management of Thai traditional medicine in new normal was created for the experiment consisted of the relationship between independent variables, namely Teaching Thai traditional medicine with emphasis on theoretical activities in terms of practice and field, on-site instruction is still needed to practice skills in each field of study.