Along with the Northeastern states of India, Odisha has a large indigenous population. For a long time, the indigenous community has been one of the most marginalized, with the highest rates of human health and well-being problems. Lack of efficient communication is a key impediment to their development as well as a crucial aspect in dealing with Maoist threats regularly. Superstition has been deeply established in their belief system as a result of a lack of education, locking them in hopeless grief and creating disease in their families. The present research paper mainly attempts to collect the knowledge of the indigenous people relating to the health care issues and challenges to develop the socio-economic condition of the study areas. According to the findings of the study, there is a link between negative behaviors such as intoxication and traditional belief practices such as traditional medicine and superstitions, as well as between government health programs and respondents' financial well-being.